The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane
receptor tyrosine kinase that is clinically
indicated in a number of carcinomas. Overexpression of the
Her2/Neu protein has been associated with ductal breast
cancer, as well as pulmonary and gastric adenocarcinomas. A
correlation between Her2/Neu and p53 has also been
documented, as overexpression of both proteins has been
associated with early invasion and metastasis in bladder
cancer